Oral exposure to Perfluorooctanoic acid disrupts the microbiota-gut-liver axis and enhances the severity of chemically induced colitis in mice.
Jungjae Park, Alessandra S. Miller, Gatha Pore, Maithili Banginwar, Sarah Lee, Jane Li, Eric Jung, Abigail Wagner, Jason Smith, Callan Malone, Ida Schoultz, Samira Salihović, Colin Reardon, Mélanie G. Gareau
This study shows that early-life PFOA exposure disrupts the gut-liver axis and worsens DSS-induced colitis in male mice but not in genetically predisposed Il10 KO mice.
Environmental Pollution · Aug 6, 2026Peer-reviewedPharmacology & Toxicology