Colin Reardon

This study shows that neonatal EPEC infection disrupts the microbiota-gut-brain axis via NOD1 signaling, leading to long-term neuroimmune and behavioral deficits, and identifies probiotic muropeptides as potential therapeutics.

This study shows that Tac1 deficiency reduces C. rodentium infection severity by lowering inflammation and immune cell recruitment.

This study shows that early-life PFOA exposure disrupts the gut-liver axis and worsens DSS-induced colitis in male mice but not in genetically predisposed Il10 KO mice.

This paper shows that vagus nerve stimulation reduces colonic inflammation in mice, but only if the colon has a history of prior inflammation.

This study shows that the sympathetic nervous system enhances immune responses to enteric bacterial infections by modulating IFN{gamma} production in CD4+ T-cells via alpha-adrenergic receptors.

This study identifies a neuroimmune circuit activated by afferent vagus nerve stimulation that reduces acute lung inflammation through epinephrine and β2-adrenergic receptor signaling.

This study shows that blocking Substance P receptor signaling reduces inflammation and prevents maladaptive responses during enteric bacterial infection without affecting host protection.