Neonatal Enteric Infection Disrupts the Microbiota-Gut-Brain Axis Through Pattern Recognition Receptors and Altered Neuroimmune Signaling
Jungjae Park, Olivia Orahood, Maithili Banginwar, Amy Andrade, Gatha Pore, Kristina Sanchez, Michael Cremin, Alessandra S. Miller, Jelissa Reynoso-Garcia, Sarah Lee, Eric Jung, Jane Li, Nidhi Kikkeri, Ingrid Brust‐Mascher, Mariana Barboza, , Mélanie G. Gareau
This study shows that neonatal EPEC infection disrupts the microbiota-gut-brain axis via NOD1 signaling, leading to long-term neuroimmune and behavioral deficits, and identifies probiotic muropeptides as potential therapeutics.
Proceedings of the National Academy of Sciences · Sep 23, 2026Peer-reviewedPhysiology