Structural insights into cobalamin loading and reactivation of human methionine synthase
Douglas S. M. Ferreira, Katie McLennan, Calum Diamond, Melanie Vollmar, Wasim Kiyani, D. Sean Froese, Jola Kopec, H. Bailey, Rod Chalk, Arnaud Baslé, Jonathan M. Elkins, Jesse A. Coker, Wyatt W. Yue, Thomas J. McCorvie
This study determines the structures of human methionine synthase in apo and cobalamin-bound states, revealing conformational changes and interactions with MMADHC and MTRR that aid in cobalamin loading and activation.
Nature Communications · May 11, 2026Peer-reviewedBiochemistry