Author

Thomas J. McCorvie

Newcastle UniversityORCID 0000-0002-1502-7113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Wyatt W. YueiD· 2 shared Aliza Imam· 1 shared Anna Kristina BjerreiD· 1 shared Annapurna Sudarsanam· 1 shared Arnaud BasléiD· 1 shared Calum Diamond· 1 shared Cassidy PetreeiD· 1 shared Charlotte L. AlstoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Wyatt W. YueORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural insights into cobalamin loading and reactivation of human methionine synthase

Douglas S. M. Ferreira, Katie McLennan, Calum Diamond, Melanie Vollmar, Wasim Kiyani, D. Sean Froese, Jola Kopec, H. Bailey, Rod Chalk, Arnaud Baslé, Jonathan M. Elkins, Jesse A. Coker, Wyatt W. Yue, Thomas J. McCorvie

This study determines the structures of human methionine synthase in apo and cobalamin-bound states, revealing conformational changes and interactions with MMADHC and MTRR that aid in cobalamin loading and activation.

Nature Communications · May 11, 2026Peer-reviewedBiochemistry

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder

James Lambton, Shotaro Asano, Yuxiang Huang, Fumi Suomi, Tomoya Eguchi, Cassidy Petree, Kevin Huang, Magali Prigent, Aliza Imam, Thomas J. McCorvie, Daniel Warren, Emma Hobson, Helen McCullagh, Doriana Misceo, Anna Kristina Bjerre, , Robert William Taylor

The paper identifies bi-allelic ATG12 variants causing a neurodevelopmental disorder by impairing autophagy, with clinical and functional evidence from patient cells, yeast, and zebrafish models.

The American Journal of Human Genetics · Mar 26, 2026Peer-reviewedGenetic & Genomic Medicine