Arnaud Baslé

Functional Differentiation of GH172 Arabinofuranosidases Through Divergent Quaternary Structures

The paper identifies functional and structural differences among three GH172 arabinofuranosidases from Dysgonomonas gadei using synthetic substrates, covalent inhibitors, and structural analysis.

Structural and functional characterisation of the dextran utilisome from Bacteroides thetaiotaomicron

This study characterizes the dextran utilisome of Bacteroides thetaiotaomicron using structural and biophysical methods, revealing its composition and dynamic behavior during dextran binding.

Structural insights into cobalamin loading and reactivation of human methionine synthase

This study determines the structures of human methionine synthase in apo and cobalamin-bound states, revealing conformational changes and interactions with MMADHC and MTRR that aid in cobalamin loading and activation.

Structural basis of iron piracy by human gut Bacteroides

This study reveals the structural mechanism by which Bacteroides thetaiotaomicron steals iron-bound siderophores from pathogens using the XusAB complex.

FragLite mapping to identify the BRD4 recruitment site of P-TEFb

The paper uses FragLites to map BRD4 recruitment sites on cyclin T2, revealing interactions with CDK9, AFF4, and HIV-1 Tat, and integrates this with biophysical and AlphaFold3 analyses to define the cyclin T-BRD4 interface.

Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

This paper identifies a novel open state of the LptDE translocon bound by a phage RBP, revealing potential for peptidomimetic inhibition and insights into phage resistance mechanisms.

A metalloenzyme's metal preference evolves through redox modulation driven by the cofactor's secondary coordination sphere

This study investigates how metal preference in SodFM enzymes evolves through redox modulation by the secondary coordination sphere, revealing a link between oxidation state and catalytic metal preference.

Discovery of a distinct BAM complex in the Bacteroidetes

The paper identifies a distinct BAM complex in Bacteroidetes using structural biology and proteomics, revealing an expanded role compared to Proteobacteria.

Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens

The paper identifies convergent evolution of D-ribulose utilisation pathways in attaching and effacing pathogens, showing how EHEC and Citrobacter rodentium exploit this nutrient for gut colonization.

BtuJ1, a novel surface-exposed B12-binding protein in Bacteroidetes, functions as an extracellular vitamin reservoir that enhances fitness.

This study identifies BtuJ1 as a B12-binding lipoprotein in Bacteroides thetaiotaomicron that functions as an extracellular vitamin reservoir, enhancing bacterial fitness in B12-limited environments.

A bacterial ribosome hibernation factor with evolutionary connections to eukaryotic protein synthesis

The paper identifies a new bacterial ribosome hibernation factor, Balon, and shows it is evolutionarily linked to eukaryotic translation factors, revealing a novel stress response mechanism.