Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia
Matías Fabregat, Rachel J. Fenske, Julia K. Hansen, Cameron J. Kaminsky, Jevin Jay Lortie, Alexander Nassar, Kaitlin A. Kressin, Annie Jen, Lucia Cilloni, Katherine A. Overmyer, Caroline M. Alexander, John W. Garrett, Perry Joseph Pickhardt, Joshua J. Coon, Costas Andreas Lyssiotis, , Andrea Galmozzi
This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.
bioRxiv · Dec 3, 2025 · PreprintCancer Biology