Rachel J. Fenske

Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

Differential expression of Ormdl genes in the islets of mice and humans with obesity

The paper examines Ormdl gene expression in islets from obese mice and humans, finding differential regulation and a role in beta-cell survival.

Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

This study shows that EP3 receptor signaling prevents insulin hypersecretion and metabolic dysfunction in non-obese insulin-resistant mice, with unexpected effects on lean mice.

Differential Effects of Prostaglandin E2 Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell Compensation

This study investigates how PGE2 production and EP3 receptor signaling affect human beta-cell function and compensation in different metabolic states.