Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility
Kate E. McCluskey, Katherine M. Stovell, Karen Law, Elina Kostyanovskaya, James D. Schmidt, Cameron R. T. Exner, Jeanselle Dea, Elise Brimble, Matthew W. State, Arthur Jeremy Willsey, Helen Rankin Willsey
This study shows autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility, with potential therapeutic benefits from serotonin signaling modulation.
Nature Communications · Mar 6, 2025Peer-reviewedNeuroscience