Author

James D. Schmidt

University of California, San FranciscoORCID 0009-0002-0085-7891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Helen Rankin WillseyiD· 4 shared Kate E. McCluskeyiD· 4 shared Arthur Jeremy WillseyiD· 3 shared Elina KostyanovskayaiD· 3 shared Jeanselle DeaiD· 3 shared Belinda WangiD· 2 shared Elise BrimbleiD· 2 shared Ethel Bader· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersDevelopmental Biology

Helen Rankin WillseyORCID

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4 papers

Recent·Most cited

Ciliary biology intersects autism and congenital heart disease

Nia Teerikorpi, Kate E. McCluskey, Ethel Bader, Micaela C. Lasser, Sheng Wang, Catherine H. Nguyen, James D. Schmidt, Elina Kostyanovskaya, Nawei Sun, Jeanselle Dea, Tomasz Jan Nowakowski, Arthur Jeremy Willsey, Helen Rankin Willsey

The paper identifies CHD genes that disrupt NPC biology and are enriched for ciliary biology, linking cilia dysfunction to ASD and CHD comorbidity.

Development · Jun 15, 2025Peer-reviewedDevelopmental Biology

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Kate E. McCluskey, Katherine M. Stovell, Karen Law, Elina Kostyanovskaya, James D. Schmidt, Cameron R. T. Exner, Jeanselle Dea, Elise Brimble, Matthew W. State, Arthur Jeremy Willsey, Helen Rankin Willsey

This study shows autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility, with potential therapeutic benefits from serotonin signaling modulation.

Nature Communications · Mar 6, 2025Peer-reviewedNeuroscience

Convergence of autism proteins at the cilium

Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, , Helen Rankin Willsey

The paper shows autism genes converge at cilia, linking them to ciliary dysfunction and co-occurring conditions.

bioRxiv · Dec 5, 2024 · PreprintCell Biology

Koolen-de Vries Syndrome causal gene KANSL1 is required for motile ciliogenesis

James D. Schmidt, Ananya Terala, Kate E. McCluskey, Belinda Wang, Anna C. Pfalzer, Helen Rankin Willsey

This study shows that KANSL1 mutations cause ciliary defects in KdVS patients, linking the gene to ciliogenesis and neurodevelopmental features.

bioRxiv · Nov 14, 2024 · PreprintDevelopmental Biology