Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in tuberous sclerosis complex and Alzheimer's disease
Farr Niere, Ayse Uneri, Colin J. McArdle, Luisa P. Cacheaux, Hailey X. Egido‐Betancourt, Sanjeev V. Namjoshi, Cameron Reynoldson, Juan Penaranda, Xin Wang, William C. Taylor, Suzanne Craft, Christopher Dirk Keene, Tao Ma, Kimberly F. Raab‐Graham
The paper identifies a novel DJ-1/2δ2/L-VDCC pathway disrupted in tuberous sclerosis and Alzheimer's disease, linking mTORC1 signaling to L-type calcium channel hypoactivity.
bioRxiv · Aug 26, 2020 · PreprintNeuroscience