Tao Ma

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy

CART-GPT predicts CAR-T therapy efficacy and neurotoxicity risk using a transformer model trained on 1.12 million single-cell RNA-seq profiles with clinical outcomes.

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease

The paper identifies five core protein kinases in neurons and astrocytes from familial AD patient iPSCs and examines their enriched pathways using a combination of experimental and in-silico approaches.

Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice

Treatment with eEF2K inhibitors and genetic eEF2K knockout improved cognitive deficits in Alzheimer's disease model mice.

Characterization of early Alzheimer's-like pathological alterations in non-human primates with aging: a pilot study

This study identifies AD-like pathological changes in older non-human primates, focusing on tau hyperphosphorylation and mitochondrial impairments in the prefrontal cortex.

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease

This study shows that reducing eIF2-P in Alzheimer's mouse models improves protein synthesis, synaptic plasticity, and memory.

Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in tuberous sclerosis complex and Alzheimer's disease

The paper identifies a novel DJ-1/2δ2/L-VDCC pathway disrupted in tuberous sclerosis and Alzheimer's disease, linking mTORC1 signaling to L-type calcium channel hypoactivity.

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.