Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice
Jiabin Tang, Cameron Swope, Kishan Patel, Azliana Jusnida Ahmad Jafri, Jiaxin Xiang, Teresa A. Milner, Hugh C. Hemmings, Jimcy Platholi
This study shows increased Nav1.3 expression in early-stage 5xFAD mice leads to CA3 hyperexcitability, suggesting Nav1.3 as a target for AD intervention.
bioRxiv · Jul 29, 2026 · PreprintNeuroscience