Hugh C. Hemmings

Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

This study shows increased Nav1.3 expression in early-stage 5xFAD mice leads to CA3 hyperexcitability, suggesting Nav1.3 as a target for AD intervention.

Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating

This study identifies a volatile anaesthetic binding site in voltage-gated sodium channels, showing it modulates channel function and reduces neuronal excitability.

Genetically engineered rapamycin responsive K2P channels

This paper genetically engineers K2P channels to be activated by rapamycin or its analogs, enabling chemogenetic control of cellular membrane potential.

Fast-acting antidepressants trigger presynaptic BDNF release and structural plasticity at mouse mossy fiber-CA3 synapses

This study shows fast-acting antidepressants like ketamine trigger BDNF release from presynaptic terminals in mouse hippocampal neurons, leading to structural plasticity in CA3 pyramidal neurons.

Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Nav1.3

This study investigates how sevoflurane affects Nav1.3 sodium channels in developing neurons, showing voltage-dependent inhibition and altered inactivation properties.

Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons

This study shows volatile anesthetics inhibit presynaptic cGMP signaling and reduce excitability in rat hippocampal neurons by affecting Ca2+ influx and neurotransmitter release.

A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus

The paper shows that a BDNF polymorphism (Val66Met) leads to persistent depression of excitatory synaptic transmission after isoflurane exposure in mice.

Differential inhibition of GABA release from mouse hippocampal interneuron subtypesby the volatile anesthetic isoflurane

This study investigates how isoflurane affects synaptic vesicle exocytosis in different hippocampal interneuron subtypes, finding subtype-specific inhibition linked to voltage-gated sodium channel expression.