Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases
Mitchell Pesesky, Ramit Bharanikumar, Lionel Le Bourhis, Hesham ElAbd, Elisa Rosati, Cara L Carty, Namita Singh, Bernd Bokemeyer, Stefan Schreiber, Siegfried Görg, Marco Garcia Noceda, Paidamoyo Chapfuwa, Rachel M Gittelman, Damon May, Jennifer N Dines, , Matthieu Allez
The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.
bioRxiv · May 15, 2024Immunology