Mitchell W. Pesesky

The paper profiles T cell receptor alpha repertoires in IBD patients across multiple cohorts, identifies disease-associated clonotypes, and validates findings in an independent dataset.

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

Seq2MAIT identifies MAIT cells from bulk TCR-sequencing data using a transformer-based model, achieving AUROC >0.80 across datasets.