Author

Lionel Le Bourhis

InsermORCID 0000-0002-7524-3539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Matthieu AlleziD· 2 shared André FrankeiD· 1 shared Anthony Sonn· 1 shared Antoine ToubertiD· 1 shared Bernd BokemeyeriD· 1 shared Bryan Howie· 1 shared Cara L. CartyiD· 1 shared Clotilde Baudry· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Matthieu AllezORCID

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2 papers

Recent·Most cited

ImmunologyJournal of Crohn s and ColitisPeer-reviewedMar 13, 2025

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases

Mitchell W. Pesesky, Ramit Bharanikumar, Lionel Le Bourhis…·Matthieu Allez

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

19 citationstop 1%

humanCITE-seq

ImmunologybioRxivPreprintNov 12, 2024

T cell mediated impairment of epithelial integrity in Crohn's disease

Sarah Hamoudi, Nassim Hammoudi, Julie Bonnereau…·Lionel Le Bourhis

This study shows that T lymphocytes from Crohn's disease patients impair intestinal epithelial integrity through increased cytotoxicity and altered immune responses in a 3D coculture model.

1 citation

humanscRNA-seq