Lipid dependence of connexin-32 gap junction channel conformations
Pia Lavriha, Carina Fluri, Jorge Enrique Hernández González, Volodymyr M. Korkhov
The paper determines the cryo-EM structures of Cx32 gap junction channels reconstituted in nanodiscs, showing that phospholipids block the pore by binding to the N-terminal gating helix, contingent on sterol presence.
Nature Communications · Dec 5, 2025Peer-reviewedBiophysics