Pia Lavriha

This study identifies HPCAL1 as a Ca2+-dependent regulator of AC8, revealing a new mechanism for cAMP signaling regulation.

The paper determines the cryo-EM structures of Cx32 gap junction channels reconstituted in nanodiscs, showing that phospholipids block the pore by binding to the N-terminal gating helix, contingent on sterol presence.

The paper identifies two distinct binding sites for connexin channel inhibitors mefloquine and 2APB, showing they block channel function through different mechanisms.

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.