Volodymyr M. Korkhov

This study designs a chimeric adenylyl cyclase (AC95) to investigate isoform-specific regulation, revealing structural insights and drug target possibilities.

This study identifies HPCAL1 as a Ca2+-dependent regulator of AC8, revealing a new mechanism for cAMP signaling regulation.

This study evaluates the impact of X-ray radiation doses on cryo-preserved biological samples, showing that high doses do not prevent subsequent cryo-EM analysis for intermediate to high-resolution structural insights.

The paper determines the cryo-EM structures of Cx32 gap junction channels reconstituted in nanodiscs, showing that phospholipids block the pore by binding to the N-terminal gating helix, contingent on sterol presence.

The paper reports cryo-EM structures of PfNCR1 bound to four inhibitors, revealing distinct binding modes that inform drug discovery targeting this malaria parasite transporter.

This study systematically identifies structure-specific protein-protein interactions using LiP-MS, demonstrating its application to alpha-synuclein in Parkinson's disease.