BioengineeringiSciencePeer-reviewed
Gradient-Based Regulation of Activin A Directs Multilineage Liver Organoid Development from Human Pluripotent Stem Cells
João P. Cotovio, Alice C. Borges, Diogo E.S. Nogueira…·Tiago G. Fernandes
This paper shows that adjusting Activin A levels in a 3D bioreactor system can generate liver-like structures from human stem cells, mimicking early liver development.
DOI 10.1016/j.isci.2026.118054