Author

João P. Cotovio

University of LisbonORCID 0000-0002-1423-5324Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:organoid / primary culture· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice C. Borges· 2 shared Joaquim M.S. Cabral· 2 shared Tiago G. FernandesiD· 2 shared Ana Rita GomesiD· 1 shared Carlos A.V. Rodrigues· 1 shared Diogo E.S. Nogueira· 1 shared Domingos HenriqueiD· 1 shared Joana E. SaraivaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioengineering

Alice C. Borges

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2 papers

Recent·Most cited

BioengineeringiSciencePeer-reviewedOct 29, 2026

Gradient-Based Regulation of Activin A Directs Multilineage Liver Organoid Development from Human Pluripotent Stem Cells

João P. Cotovio, Alice C. Borges, Diogo E.S. Nogueira…·Tiago G. Fernandes

This paper shows that adjusting Activin A levels in a 3D bioreactor system can generate liver-like structures from human stem cells, mimicking early liver development.

DOI 10.1016/j.isci.2026.118054

humanorganoid / primary culture

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BioengineeringbioRxivPreprintAug 25, 2026

Transcriptomic Analysis Identifies Transient Mesendodermal State and Lineage Divergence in Human Pluripotent Stem Cell Differentiation

Alice C. Borges, Mariana A. Branco, João P. Cotovio…·Tiago G. Fernandes

DOI 10.64898/2026.08.24.746642

humanbulk RNA-seq

𝕏 PostBluesky