Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding
Qingquan Chen, Pam Cai, Tony Hong Wei Chang, Elizabeth Burgener, Michael J. Kratochvil, Aditi Gupta, Aviv Hargil, Patrick R. Secor, Josefine Eilsø Nielsen, Annelise E. Barron, Carlos Milla, Sarah C. Heilshorn, A. J. Spakowitz, Paul L. Bollyky
This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.
bioRxiv · Mar 10, 2024 · PreprintMicrobiology