Paul L. Bollyky

The paper develops PhageScan to study human antibody responses to bacteriophages, finding widespread IgG reactivity and identifying immunogenic epitopes.

The paper develops and optimizes two protocols for purifying ssDNA from filamentous phages using chaotropic salts and silica columns, achieving high recovery and purity comparable to commercial kits.

The paper examines the association between phage and antibiotic resistance in Pseudomonas aeruginosa clinical isolates and finds a positive correlation between the two resistance phenotypes.

This study compares genome features of Pseudomonas aeruginosa isolates from cystic fibrosis patients and environmental sources, finding smaller genomes and shorter prophage sequences in clinical isolates.

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

This paper develops a single-step chromatography method to purify Pseudomonas aeruginosa phages with high endotoxin reduction and protein impurity removal, suitable for therapeutic use.

This study identifies HA and CD44 as mediators of matrix changes and fibrosis in PSC, showing their targeting can reverse disease progression.

This study identifies a novel mechanism by which Pseudomonas aeruginosa acquires iron through a partnership with filamentous phages, enhancing bacterial growth and pathogenesis.

This study shows T cells generate migration paths in confining ECMs by tearing them apart with breaststroke-like motion, finding that shear strength, not stiffness or pore size, correlates with migration.

This study analyzes 186 Pseudomonas aeruginosa clinical isolates to assess the association between prophage presence and antibiotic resistance, finding few significant links.

This paper develops a physiologically based pharmacokinetic model to characterize the whole-body distribution of bacteriophages in mice, finding rapid elimination and the need for multi-dose regimens.

The paper investigates Pf phage transmission in Pseudomonas aeruginosa airway infections in cystic fibrosis patients, finding vertical transmission within lineages and new superinfections by Pf+ strains.

This paper develops broad-spectrum bacteriophage therapy cocktails effective against multiple bacterial strains and infections.

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

The paper identifies bacterial receptor genes determining phage host range, showing defense mechanisms are not predictive of susceptibility.

This study investigates the role of endogenous IL-10 in murine wound healing, finding no effect on closure rates but increased inflammation and scarring in its absence.