The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes
Susanne Schleifenbaum, Aljoscha Swoboda, Johannes Dirks, Claudia Bracaglia, Ivan Caiello, Tanja Hinze, Sven Hardt, Giusi Prencipe, Giusyda Tarantino, Manuela Pardeo, Sabrina Fuehner, Carolin Park, Claas H. Hinze, Helmut Wittkowski, Daniel Windschall, , Christoph Kessel
This study compares how synovial fluid from systemic juvenile idiopathic arthritis (sJIA) and JIA patients influences T helper cell polarization, showing sJIA SF promotes a specific Tph phenotype linked to IL-1β, IL-18, and GM-CSF.
bioRxiv · Jul 1, 2025 · PreprintImmunology