IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration
Alessandro Cutilli, Suze A Jansen, Francesca Paolucci, Marliek van Hoesel, Cynthia L Frederiks, Tessa A M Mulder, Theofilos Chalkiadakis, Michal Mokry, Stefan Prekovic, Enric Mocholi, Caroline A Lindemans, Paul J Coffer
This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.
bioRxiv · Feb 3, 2024Immunology