Michal Mokrý

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

The paper generates intestinal organoids from pediatric IBD patients and controls to study epithelial phenotypes linked to genetic drivers of the disease, identifying gene expression patterns and pathways associated with inflammation.

The paper uses CROP-seq to identify histone modifying enzymes regulating inflammatory macrophage activation, finding Kdm5c modulates inflammatory responses by balancing baseline and inducible activation.

The paper links ADAR1-mediated RNA editing in smooth muscle cells to regulation of MDA5 activation, showing its role in atherosclerosis progression and vascular calcification.

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

This study investigates the association between kynurenine and NAD+ pathway metabolites and macrophage content and polarization in carotid plaques, finding higher kynurenine levels correlate with M1 macrophages and reduced NAD+.

The paper identifies female-biased VSMC gene regulatory networks and highlights MYH9 as a key regulator of fibrous plaque phenotype in females.

The paper investigates how human intestinal epithelial cells respond to bacterial antigens, finding that stem cells are the primary responders and that WNT signaling plays a key role in regulating microbial responses.

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

The paper maps sex-dependent gene activity across 24 human tissues using RNA-sequencing data and identifies sex-biased genes and pathways.

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.