Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Aaron J Sams, Anne Dumaine, Johann Nédélec, Vania Yotova, Caroline Alfieri, Jerome E Tanner, Philipp W Messer, Luis B Barreiro
The paper identifies a Neandertal haplotype at the OAS locus that affects innate immune responses by altering OAS gene expression and splice variants in humans.
bioRxiv · Sep 12, 2016Evolutionary Biology