Vania Yotova

Reply to Barton et al: signatures of natural selection during the Black Death

The paper addresses statistical concerns about detecting natural selection during the Black Death using ancient genomic data, reaffirming findings related to immune loci and the ERAP2 variant.

Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection

The paper shows ancestry-related differences in transcriptional response to influenza are driven by epigenetic variation and genetic control of enhancer activity.

Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV

The paper investigates how HIV and antiretroviral therapy affect the transcriptional and epigenetic response of alveolar macrophages to Mycobacterium tuberculosis.

Gene activation precedes DNA demethylation in response to infection in human dendritic cells

The paper shows that gene expression changes precede DNA demethylation in human dendritic cells during infection with Mycobacterium tuberculosis.

Widespread shortening of 3’ untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection

The paper identifies widespread changes in RNA processing, including shorter 3’ UTRs and increased exon inclusion, in innate immune responses across humans and non-human primates.

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

The paper identifies a Neandertal haplotype at the OAS locus that affects innate immune responses by altering OAS gene expression and splice variants in humans.

Bacterial Infection Remodels the DNA Methylation Landscape of Human Dendritic Cells

This study shows that bacterial infection rapidly alters DNA methylation in human dendritic cells, affecting enhancer elements and gene expression related to immune responses.