Author

Philipp W Messer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dmitri Petrov· 2 shared Aaron J Sams· 1 shared Adam R Boyko· 1 shared Andrew G Clark· 1 shared Anne Dumaine· 1 shared Benjamin A Wilson· 1 shared Caroline Alfieri· 1 shared Florencia Schlamp· 1 shared

Activity by Year

2014-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

Dmitri Petrov

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

Aaron J Sams, Anne Dumaine, Johann Nédélec, Vania Yotova, Caroline Alfieri, Jerome E Tanner, Philipp W Messer, Luis B Barreiro

The paper identifies a Neandertal haplotype at the OAS locus that affects innate immune responses by altering OAS gene expression and splice variants in humans.

bioRxiv · Sep 12, 2016Evolutionary Biology

Evolution of resistance against CRISPR/Cas9 gene drive

Robert L Unckless, Andrew G Clark, Philipp W Messer

This study shows resistance against CRISPR/Cas9 gene drive will inevitably evolve unless specific conditions are met, and highlights the need for careful modeling before releasing driver constructs.

bioRxiv · Jun 11, 2016Evolutionary Biology

Evaluating the performance of selection scans to detect selective sweeps in domestic dogs

Florencia Schlamp, Julian van der Made, Rebecca Stambler, Lewis Chesebrough, Adam R Boyko, Philipp W Messer

The paper evaluates selection scans for detecting selective sweeps in domestic dogs by analyzing genomic signatures around known causal mutations in 25 breeds.

bioRxiv · Oct 8, 2015Evolutionary Biology

Quantification of GC-biased gene conversion in the human genome

Sylvain Glemin, Peter F Arndt, Philipp W Messer, Dmitri Petrov, Nicolas Galtier, Laurent Duret

This paper quantifies GC-biased gene conversion (gBGC) in the human genome using a new method that accounts for polarization errors and spatial heterogeneity, revealing that gBGC is concentrated in recombination hotspots.

bioRxiv · Oct 9, 2014Evolutionary Biology

Soft selective sweeps in complex demographic scenarios

Benjamin A Wilson, Dmitri Petrov, Philipp W Messer

This study extends the theory of soft selective sweeps to realistic demographic scenarios, showing how population bottlenecks and fluctuating population sizes affect the likelihood of observing soft sweeps.

Genetics · Jul 24, 2014Peer-reviewedEvolutionary Biology