Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs
Catherine Marin Della Santina, Deon S. Ploessl, Nicole Lindsay‐Mosher, Caroline G. Brown, Mary Elisabeth Ehmann, Albert Blanch-Asensio, Eung Chang Kim, Edward S. Boyden, Kate E. Galloway, Laurie A. Boyer
This paper demonstrates that self-amplifying RNA (saRNA) enables durable, integration-free transgene expression in hiPSCs, supporting cell-fate programming and functional reporter analysis.
Cell Reports Methods · Sep 1, 2026Peer-reviewedBioengineering