Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A
Garyfallia Papaioannou, Tadatoshi Sato, Caroline Houghton, Parthena E. Kotsalidis, Katelyn Strauss, Thomas Dean, Alissa J. Nelson, Matthew P. Stokes, Thomas James Gardella, Marc Nathan Wein
This study identifies FAK's role in regulating cAMP levels in osteocytes through PDE8A, showing FAK inhibition increases cAMP and downstream signaling.
bioRxiv · Jun 28, 2024 · PreprintMolecular Biology