Marc Nathan Wein

Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival

This study shows FGFR1 signaling is essential for osteocyte survival and bone homeostasis by regulating extracellular matrix organization and dendrite formation in maturing osteoblasts.

CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types

The paper shows that CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across multiple cell types, challenging the canonical model of CREB1 activation.

Intermittent parathyroid hormone employs autonomous and non-autonomous mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells

This study shows intermittent parathyroid hormone drives osteogenesis from Ebf3-expressing progenitors via both intrinsic and extrinsic mechanisms in mice and humans.

Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology

The paper uses a CRISPRi screen to identify Clip2 as a regulator of osteocyte maturation and morphology by analyzing CD61 expression and dendrite formation.

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

Trafficking and translation of mRNA in osteocyte dendrites

This study identifies mRNA localization sequences in osteocyte dendrites and shows they are translated locally, revealing a mechanism for regulating dendrite structure and function.

Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A

This study identifies FAK's role in regulating cAMP levels in osteocytes through PDE8A, showing FAK inhibition increases cAMP and downstream signaling.

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.