Single cell long-read genotyping of transcriptomes reveals discrete mechanisms of clonal evolution in post-myeloproliferative neoplasm acute myeloid leukemia.
Julian Grabek, Jasmin Straube, Leanne T. Cooper, Rohit Haldar, Ranran Zhang, Inken Dulige, Matthew A Barker, William Gatehouse, Helen Christensen, Gerlinda M. Amor, Victoria Ling, Caroline McNamara, David M. Ross, Andrew Charles Perkins, Megan J. Bywater, Steven Lane
This study uses a new long-read sequencing method to genotype mutations in single cells from MPN patients, revealing how mutations drive disease progression to AML.
Blood Advances · May 8, 2026Peer-reviewedCancer Biology