Jasmin Straube

Dnmt3a-mutant Leukemia Stem Cells evade chemotherapy through enforced quiescence in Npm1c-Flt3ITD Acute Myeloid Leukemia

This study shows that DNMT3A mutations in AML promote chemotherapy resistance by enforcing quiescence in leukemia stem cells, which can be reversed with pegIFN to restore sensitivity.

Single cell long-read genotyping of transcriptomes reveals discrete mechanisms of clonal evolution in post-myeloproliferative neoplasm acute myeloid leukemia.

This study uses a new long-read sequencing method to genotype mutations in single cells from MPN patients, revealing how mutations drive disease progression to AML.

A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

This study shows that modified mRNA encoding Myc and Cyclin T1 can induce cardiomyocyte proliferation and improve cardiac function after myocardial injury in mice.