Steven Lane

This study shows that DNMT3A mutations in AML promote chemotherapy resistance by enforcing quiescence in leukemia stem cells, which can be reversed with pegIFN to restore sensitivity.

This study shows that CSF1R-dependent macrophages are essential for hematopoiesis but many functions of tissue resident macrophages are redundant or strain-specific in mice.

This study uses a new long-read sequencing method to genotype mutations in single cells from MPN patients, revealing how mutations drive disease progression to AML.

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.