Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition
Chiara Asselborn, Agata N Makar, Jair G Marques, Aslıhan Bastem Akan, Athanasia Yiapanas, Carrie Jennings, Ana Pérez López, Jimi C. Wills, Asier Unciti‐Broceta, Kevin Myant, Alex von Kriegsheim
This study identifies Molidustat's anti-tumor effect in APC-mutant colorectal cancer through co-inhibition of GSTP1 and PHD2, revealing a synthetic lethal interaction.
bioRxiv · May 4, 2026 · PreprintCancer Biology