GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells
Cesi Deng, Adedamola Elujoba-Bridenstine, Ai Tang Song, Rylie M. Ceplina, Casey J. Ostheimer, Molly C. Pellitteri-Hahn, Cameron O. Scarlett, Sahitya Saka, Xuan Pan, Owen J. Tamplin
This study identifies GABA as a regulator of HSPCs produced by B cells and endothelial cells in the bone marrow, showing lower GABA levels reduce proliferation and increase B cell differentiation.
Stem Cell Reports · Oct 16, 2025Peer-reviewedCell Biology