Xuan Pan

Yin Yang 1-dependent TET2 regulation is essential for early T cell development

This study shows that YY1 REPO domain regulates TET2 expression, which is essential for T cell development, and that disrupting this regulation causes developmental defects.

YY1-Mediated Polycomb Group Function Safeguards Hematopoietic Stem Cells from Premature Aging

This study shows that YY1's Polycomb group function is essential for maintaining HSC quiescence and preventing premature aging.

GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells

This study identifies GABA as a regulator of HSPCs produced by B cells and endothelial cells in the bone marrow, showing lower GABA levels reduce proliferation and increase B cell differentiation.