Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.
Sabrina R. Mackinnon, Tryfon Zarganes‐Tzitzikas, Cassandra J. Adams, Paul E. Brennan, Wyatt W. Yue
This paper introduces a luminescence-based CETSA method to measure HAO1 inhibitor uptake and engagement, showing it can differentiate ligand permeability and engagement profiles.
Biochimie · Aug 14, 2024Peer-reviewedBiochemistry