Author

Sabrina R. Mackinnon

Newcastle UniversityORCID 0000-0002-6816-244XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Cassandra J. Adams· 1 shared Paul E. BrennaniD· 1 shared Tryfon Zarganes‐TzitzikasiD· 1 shared Wyatt W. YueiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Cassandra J. Adams

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1 paper

Recent·Most cited

BiochemistryBiochimiePeer-reviewedAug 14, 2024

Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.

Sabrina R. Mackinnon, Tryfon Zarganes‐Tzitzikas, Cassandra J. Adams…·Wyatt W. Yue

This paper introduces a luminescence-based CETSA method to measure HAO1 inhibitor uptake and engagement, showing it can differentiate ligand permeability and engagement profiles.

3 citations

humanproteomics

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