Author
University of OxfordORCID 0000-0001-7323-8587Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Darragh Patrick O'Brien, Hannah B. L. Jones, Yuqi Shi…·Benedikt Mathias Kessler
This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.
Sabrina R. Mackinnon, Tryfon Zarganes‐Tzitzikas, Cassandra J. Adams…·Wyatt W. Yue
This paper introduces a luminescence-based CETSA method to measure HAO1 inhibitor uptake and engagement, showing it can differentiate ligand permeability and engagement profiles.
Ryan M. Lithgo, Charles W.E. Tomlinson, M. Fairhead…·F. von Delft
This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.