Glutaminolysis promotes the function of follicular helper T cells in lupus-prone mice
Seung Chul Choi, Yong Ge, Milind V. Joshi, Damian Jimenez, Lauren T. Padilla, Cassandra LaPlante, Jeffrey C. Rathmell, Mansour Mohamadzadeh, Laurence M Morel
This study shows that glutaminolysis supports lupus Tfh cell function, and its inhibition reduces autoantibody production and disease in lupus-prone mice.
bioRxiv · Nov 25, 2024 · PreprintImmunology