Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress
Jonathan Gigas, Michael E. Meadow, Jing Guo, Catherine Lan, Eric C. Hillpot, John C. Martinez, Gregory Tombline, Philip M. Bellomio, Valeria Rivera-Almodóvar, Kevin A. Welle, Kyle Swovick, Jennifer R. Hryhorenko, Julia Ablaeva, Sina Ghaemmaghami, Andrei Seluanov, Vera A. Gorbunova
This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.
GeroScience · Jul 8, 2026Peer-reviewedMolecular Biology