Author
John C. Martinez
University of RochesterORCID 0000-0003-0040-8519Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 43 mutual co-author links5 papers
Recent·Most cited
- Cell BiologyNature AgingPeer-reviewed
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation
John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner…·Vera A. Gorbunova
This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.
16 citationstop 2% - Molecular BiologyGeroSciencePeer-reviewed
Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress
Jonathan Gigas, Michael E. Meadow, Jing Guo…·Vera A. Gorbunova
This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.
DOI 10.1007/s11357-026-02389-3 - Molecular BiologybioRxivPreprint
SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice
Seyed Ali Biashad, Eric C. Hillpot, Francesco Morandini…·Vera A. Gorbunova
This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.
5 citations - Developmental BiologyeLifePeer-reviewed
MicroRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling
Shumin Wang, Eri O. Maruyama, John C. Martinez…·Takamitsu Maruyama
This study identifies miR-27a as essential for bone remodeling by regulating p62-mediated osteoclast signaling, leading to severe osteoporosis in mice.
12 citations