Author

Jonathan Gigas

University of RochesterORCID 0000-0002-0458-3181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Andrei SeluanoviD· 2 shared Eric C. Hillpot· 2 shared Vera A. GorbunovaiD· 2 shared Aaron J. WolfeiD· 1 shared Adam D. HudginsiD· 1 shared Advait AthreyaiD· 1 shared Alexis Pope· 1 shared Archana Tare· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Andrei SeluanovORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

Jonathan Gigas, Michael E. Meadow, Jing Guo, Catherine Lan, Eric C. Hillpot, John C. Martinez, Gregory Tombline, Philip M. Bellomio, Valeria Rivera-Almodóvar, Kevin A. Welle, Kyle Swovick, Jennifer R. Hryhorenko, Julia Ablaeva, Sina Ghaemmaghami, Andrei Seluanov, Vera A. Gorbunova

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

GeroScience · Jul 8, 2026Peer-reviewedMolecular Biology

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Matthew A. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Eric C. Hillpot, Lei Justan Zhang, Maria Zagorulya, Greg Tombline, Michael B. Gilbert, Samantha L. Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Denis Firsanov, Advait Athreya, , Vera A. Gorbunova

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

The EMBO Journal · Oct 10, 2022Peer-reviewedMolecular Biology