Proteome capacity constraints favor respiratory ATP generation
Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Catherine M. Call, Heide Baron, Rolf-Peter Ryseck, Jimmy Pratas, Arjuna M. Subramanian, Zia Fatma, Daniel Weilandt, Sudharsan Dwaraknath, Tianxia Xiao, John I. Hendry, Vinh Gia Tran, Lifeng Yang, , Joshua D. Rabinowitz
The paper shows mitochondrial respiration is more proteome-efficient than aerobic glycolysis in yeast and mammals, with flexibility arising from maintaining a fermentation-capable proteome.
bioRxiv · Aug 10, 2022 · PreprintSystems Biology