Imbalance of Ciliary Programs Drives Fibroblast Differentiation and Fibrotic Signaling in Systemic Sclerosis
Le My Tu Nguyen, Carlos E. Córdova, Paulene Sapao, Catherine Vasquez-Hernandez, Adam Klumpp, Le Phuc Diem Nguyen, Poulami Dey, Johann Eli Gudjonsson, Rebecca L. Ross, Francesco Del Galdo, Natalia A. Riobo‐Del Galdo, Priyanka Verma, John Varga, Maria Eugenia Teves
This study identifies ciliary program imbalance as a driver of fibroblast-to-myofibroblast reprogramming in systemic sclerosis, suggesting ciliotherapy as a potential treatment.
bioRxiv · Feb 25, 2026 · PreprintCell Biology