Johann Eli Gudjonsson

Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) response

This study identifies VISTA as a suppressor of UV-induced IFN-I responses in keratinocytes, reducing skin injury in mice and human cells.

IFN-κ directs antiviral immunity in human skin

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

Genome-scale perturbation signatures from primary human CD4+ T cells improve genetics-based prioritization of immune drug targets

The paper introduces IGNITE, a framework that combines genetic data with functional genomics to prioritize immune drug targets, showing improved performance over genetic methods alone.

Disease context dictates the cellular targets of IL-17 in inflammatory skin disease

This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.

Multiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey Disease

This study uses multiomic analysis to identify IFN signaling as a key driver in Hailey-Hailey disease and shows that ruxolitinib treatment reduces inflammation and improves patient outcomes.

Disease-specific differences in particulate matter handling drive pathogenic responses in human derived nasal epithelial cells

The paper investigates how particulate matter exposure affects nasal epithelial cells in chronic rhinosinusitis (CRS) and controls, finding amplified inflammatory and barrier dysfunction responses in CRS cells.

Hailey-Hailey disease models identify synergistic therapeutic effects of MEK and ROCK inhibition

This study uses human keratinocyte models of Hailey-Hailey disease to show that combined MEK and ROCK inhibition restores epidermal integrity, suggesting a therapeutic strategy for this genetic skin disorder.

Semi-parametric Empirical Bayes Method for Multiplet Detection in snATAC-seq with Probabilistic Multi-omic Integration

SEBULA detects multiplets in snATAC-seq using a semi-parametric empirical Bayes model and integrates with scRNA-seq data, showing superior performance on benchmark datasets.

Keratin 16 spatially inhibits type I interferon responses in stressed and diseased skin

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

singIST: an integrative method for comparative single-cell trancriptomics between disease models and humans

singIST quantifies disease model similarity to human conditions at single-cell resolution using pathway and cell type-level measures, demonstrating its utility in atopic dermatitis models.

Restoration of Keratinocyte Homeostasis Drives Resolution of Skin Inflammation

The paper shows that restoring keratinocyte homeostasis reduces skin inflammation by reversing gene programs and normalizing epidermal architecture in a murine model.

Imbalance of Ciliary Programs Drives Fibroblast Differentiation and Fibrotic Signaling in Systemic Sclerosis

This study identifies ciliary program imbalance as a driver of fibroblast-to-myofibroblast reprogramming in systemic sclerosis, suggesting ciliotherapy as a potential treatment.

Seq-Scope-eXpanded: Spatial Omics Beyond Optical Resolution

Seq-Scope-X improves spatial transcriptomics resolution by expanding tissues, revealing detailed nuclear and cytoplasmic transcriptome differences in liver cells and enabling proteomic analysis in other tissues.

A single cell and spatial genomics atlas of human skin fibroblasts in health and disease

This study creates a spatial genomics atlas of human skin fibroblasts in health and disease, identifying six major populations and three disease-specific subtypes.

IgG autoantibodies in bullous pemphigoid directly induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes:

This study shows that BP-IgG autoantibodies induce a pro-inflammatory response in keratinocytes via MyD88-dependent signaling, contributing to BP pathology.

The endoplasmic reticulum autophagy receptor TEX264 drives epidermal differentiation and is dysregulated in Darier disease

This study identifies TEX264 as a key driver of epidermal differentiation through reticulophagy, showing its dysregulation in Darier disease.

Cross-disease comparison of dermatomyositis and lupus skin identifies inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis

This study compares dermatomyositis and lupus skin lesions using single-cell RNA-sequencing to identify inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis.

Loopsim: Enrichment Analysis of ChromosomeConformation Capture with Fast EmpiricalDistribution Simulation

Loopsim performs enrichment analysis on Hi-C loop profiles by simulating empirical null distributions to assess statistical significance of loop features.

TWEAK Signaling Drives the Transition from Psoriasis to Atopic Dermatitis-like Inflammation in Paradoxical Skin Reactions

The paper identifies TWEAK-IL-13 signaling as a driver of paradoxical skin reactions following anti-TNF, IL-17, or IL-23 therapy.

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

Pemphigus vulgaris autoantibodies induce an ER stress response

This study shows that PV autoantibodies trigger ER stress, leading to desmosome disruption and cell adhesion loss, and suggests ER stress as a therapeutic target.

ERK hyperactivation in epidermal keratinocytes impairs intercellular adhesion and drives Grover disease pathology

This study shows ERK hyperactivation in keratinocytes causes impaired adhesion and drives Grover disease, supporting MEK inhibition as a potential therapy.

Multi-Ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis

This study conducts a multi-ancestry GWAS meta-analysis of 56,146 AD cases and 602,280 controls, identifying 101 genomic loci, 15 novel to AD or eczema, and linking them to AD pathophysiology through functional analyses.

tauFisher accurately predicts circadian time from a single sample of bulk and single-cell transcriptomic data

tauFisher predicts circadian time from bulk and single-cell transcriptomic data by analyzing rhythmic gene correlations, showing strong performance across multiple tissues and experimental settings.

Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis

This paper performs RNA-seq on skin samples from three acantholytic diseases to identify shared transcriptomic features and mechanisms of pathogenesis.

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.