Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage {varphi}2638A
Léa V. Zinsli, Anna M. Sobieraj, Patrick J. Ernst, Susanne Meile, Samuel Kilcher, Cedric Iseli, Anja P. Keller, Birgit Dreier, Peer R. E. Mittl, Andreas Plückthun, Martin J. Loessner, Mathias Schmelcher, Matthew Dunne
This study investigates the role of SV isoforms of the staphylococcal phage φ2638A endolysin during infection, showing they form heterodimers with the full-length endolysin to enhance lytic activity.
bioRxiv · Jan 16, 2024 · PreprintMolecular Biology